Winslow lab




Winters IP, Chiou S-H, Paulk NK, McFarland CD, Lalgudi PV, Ma RK, Lisowski L, Connolly AJ, Petrov DA, Kay MA, Winslow MM. Multiplex in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity. Nat Commun. 2017 Dec 12; 8(1): 2053. doi: 10. 1038/s41467-017-01519-y.


Chiou S-H, Risca VI, Wang GX, Yang D, Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, Castellini L, Graves EE, Kim GE, Mourrain P, Koong AC, Giaccia AJ, Winslow MM. Blimp1 induces transient metastatic heterogenity in pancreatic cancer. Cancer Discovery, 2017 Oct; Volume 7(10): 1184-99


Gocheva V, Naba A, Bhutkar A, Guardia T, Miller KM, Li CM, Dayton TL, Sanchez-Riera FJ, Kim-Kiselak C, Jaikhni N, Winslow MM, Del Rosario A, Hynes RO, Jacks T. Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survivial.Proc Natl Acad Sci USA, 2017 Jul; 114(28): E5625-E5634


Rogers ZN*, McFarland CD*, Winter IP*, Naranjo S, Chuang C-H, Petrov D, and Winslow MM. A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo. Nature Methods, 2017 July; 14(7); 737-742

*Co-first authors


Chuang C-H, Greenside PG, Rogers ZN, Brady JJ, Yang D, Ma RK, Caswell DR, Chiou S-H, Winters A, Grüner BM, Ramaswami G, Spencley AL, Kopecky KE, Sayles LC, Sweet-Cordero EA, Li JB, Kundaje A, and Winslow MM. Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Jak-Stat axis. Nature Medicine, 2017 Mar; 23(3):291-300



Grüner BM*, Schulze CJ*, Yang D, Ogasawara D, Dix MM, Rogers ZR, Chuang C-H, McFarland CD, Chiou S-H, Brown JM, Cravatt BF, Bogyo M**, Winslow MM** An in vivo multiplexed small molecule screening platform.Nature Methods, 2016 Oct;13(10):883-9 *Co-first authors ** Co-senior authors


Weiskopf K, Jahchan NS, Schnorr PJ, Cristea S, Ring AM, Maute RL, Volkmer AK, Volkmer JP, Liu J. Lim JS, Yang D, Seitz G, Nguyen T, Wu D, Jude K, Guerston H, Barkal A, Trapani F, George J, Poirier JT, Gardner EE, Miles LA, de Stanchina E, Lofgren SM, Vogel H, Winslow MM, Dive C, Thomas RK, Rudin CM, van de Rijn M, Majeti R, Garcia KC, Weissman IL, Sage J. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. Journal of Clinical Investigation. 2016 Jul 1; 126(7):2610-20


Denny SK*, Yang D*, Chuang CH, Brady JJ, Lim JS, Grüner BM, Chiou SH, Schep AN, Baral J, Hamard C, Antoine M, Wislez M, Kong CS, Connolly AJ, Park KS, Sage J**, Greenleaf WJ**, Winslow MM**.Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility. Cell. 2016 July *Co-first authors ** Co-senior authors


Brady JJ, Chuang CH, Greenside PG, Rogers ZN, Murray CW, Caswell DR, Hartmann U, Connolly AJ, Sweet-Cordero EA, Kundaje A, Winslow MM. An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency. Cancer Cell. 2016 Volume 29(5); 697-710



Chiou S-H*, Winters IP*, Wang J, Naranjo S, Dudgeon C, Tambuini FB, Brady JJ, Yang D, Gruner BM, Chuang C-H, Cawell DR, Zeng H, Chu P, Kim GE, Carpizo DR, Kim SK, Winslow MM. Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing. Genes and Development, 2015 Volume 29(14);1576-85 *Co-first authors


Ofori LO, Withana NP, Prestwood TR, Verdoes M, Brady JJ, Winslow MM, Sorger J, Bogyo M. Design of protease activated optical contrast agents that exploit a latent lysosomotropic effect for use in fluorescence-guided surgery. ACS Chemical Biology 2015 Volume 10(9): 1977-88


Valdmanis PN, Roy-Chaudhuri B, Kim HK, Sayles LC, Zheng Y, Chuang CH, Caswell DR, Chu K, Zhang Y, Winslow MM, Sweet-Cordero EA, Kay MA. Upregulation of the microRNA cluster at the Dlk1-Dio3 locus in lung adenocarcinoma. Oncogene. 2015 Jan 2;34(1):94-103


Robles-Oteiza C, Taylor S, Yates T, Cicchini M, Lauderback B, Cashman CR, Burds AA, Winslow MM, Jacks T, Feldser DM.

Recombinase-based conditional and reversible gene regulation via XTR alleles. Nature Communications 2015 Nov 5;6:8783


Madison BB, Jeganathan AN, Mizuno R, Winslow MM, Castells A, Cuatrecasas M, Rustgi AK. Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2. PLoS Genetics 2015 Aug 5;11(8)



Goodwin JM, Svensson RU, Lou HJ, Winslow MM, Turk BE, Shaw RJ. An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential. Molecular Cell. 2014 Jul 16. pii: S1097-2765(14)00529-2. [Epub ahead of print]


Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, Kim CF. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proc Natl Acad Sci U S A. 2014; 111(28):10299-304.


Chiou S-H, Kim-Kiselak C, Risca VI, Heimann M, Chuang C-H, Burds AA, Greenleaf WJ, Jacks TE, Feldser DM, and Winslow MM. A conditional system to specifically link disruption of protein coding function with reporter expression in mice. Cell Reports, 2014 Jun 26;7(6):2078-86.


Caswell DR, Chuang CH, Yang D, Chiou SH, Cheemalavagu S, Kim-Kiselak C, Connolly A, Winslow MM. Obligate progression precedes lung adenocarinoma dissemination. Cancer Discovery, 2014 Jul;4(7):781-9.



Li CM, Chen G, Dayton TL, Kim-Kiselak C, Hoersch S, Whittaker CA, Bronson RT, Beer DG, Winslow MM, Jacks T. Differential Tks5 isoform expression contributes to metastatic invasion of lung adenocarcinoma. Genes and Development. 2013 Jul 15;27(14):1557-67. doi: 10.1101/gad.222745.113.


Rice SJ, Lai SC, Wood LW, Helsley KR, Runkle EA, Winslow MM, Mu D. (2013) MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1). Journal of Biological Chemistry, 2013 Jun 7;288(23):16348-60. doi: 10.1074/jbc.M113.474643. Epub 2013 Apr 26.


Byun S, Son S, Amodei D, Cermak N, Shaw J, Kang JH, Hecht VC, Winslow MM, Jacks T, Mallick P, Manalis SR. (2013) Characterizing deformability and surface friction of cancer cells. Proc Natl Acad Sci USA. 2013 Apr 22. [Epub ahead of print]



Reticker-Flynn NE, Malta DF, Winslow MM, Lamar JM, Xu MJ, Underhill GH, Hynes RO, Jacks TE, Bhatia SN. A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nature Communications, (2012) 3:1122. doi: 10.1038/ncomms2128.


Runkle EA, Rice SJ, Qi J, Masser D, Antonetti DA, Winslow MM, Mu D. Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1). Journal of Biological Chemistry, (2012) Aug 17;287(34):28790-801. doi: 10.1074/jbc.M112.367987. Epub 2012 Jul 2.

Related citations



Winslow MM, Dayton TL, Verhaak RG, Kim-Kiselak C, Snyder EL, Feldser DM, Hubbard DD, DuPage MJ, Whittaker CA, Hoersch S, Yoon S, Crowley D, Bronson RT, Chiang DY, Meyerson M, and Jacks T. Suppression of Lung Adenocarcinoma Progression by Nkx2-1. Nature, 2011 Volume 473(7345), 101-104.


Schroeder A*, Heller DA*, Winslow MM*, Dahlman JE*, Pratt GW, Langer R, Jacks T, Anderson DG. Treating metastatic cancer with nanotechnology. Nature Reviews Cancer, 2011 Volume 12(1), 39-50. *Contributed Equally

Xue W, Meylan E, Oliver TO, Feldser DM, Winslow MM, Bronson R, Jacks T. Response and resistance to NF-kB inhibitors in mouse models of lung adenocarcinoma. Cancer Discovery, 2011 Volume 1(3), 236-247.

Dooley AL, Winslow MM, Chiang DY, Banerji S, Stransky N, Dayton TL, Snyder E, Senna S, Whittaker CA, Bronson RT, Crowley D, Barretina J, Garraway L, Meyerson M, and Jacks T. Nuclear factor I/B is a proto-oncogene in Small Cell Lung Cancer. Genes and Development, 2011 Volume 25(14), 1470-1475.

Shaw AT, Winslow MM, Magendantz M, Ouyang C, Dowdle J, Subramanian A, Lamb J, Lewis T, Maglathin R, Tolliday N, and Jacks T. Selective Killing of K-ras Mutant Cancer Cells by Novel, Small Molecule Inducers of Oxidative Stress. Proceedings of the National Academy of Sciences, 2011Volume 108(21), 8773-8778.


DuPage MJ, Cheung A, Mazumdar C, Winslow MM, Bronson RT, Crowley D, Chen J, and Jacks T. Endogenous T cell responses to lung adenocarcinoma neoantigens delay tumor progression. Cancer Cell, 2011 19(1), 72-85.



Feldser DM, Kostova KK, Winslow MM, Sanchez-Rivera F, Whittaker C, Taylor S, Cashman C, Resnick R, Bronson R, Hemann MT, and Jacks T. Stage-specific sensitivity to p53 restoration during lung tumor progression. Nature, 2010 Volume 468(7323), 572-575.



Ventura A, Garfinkel AG*, Winslow MM*, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JA, Jaenisch R, Sharp PA, Jacks T. Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17~92 Family of miRNA Clusters. Cell, 2008 Volume 132(5), 875-886. *Contributed equally.


Gallo EM, Ho L, Winslow MM, Staton TL, Crabtree GR. Selective role of calcineurin in haematopoiesis and lymphopoiesis. EMBO Reports 2008 Nov; 9(11):1141-8. doi: 10.1038/embor.2008.174. Epub 2008 Sep 26.



Gallo EM, Winslow MM, Cante-Barrett K, Radermacher AN, Ho L, Neilson JR, McGinnis L, Iritani B, and Crabtree GR. (2007) Calcineurin sets the bandwidth for discrimination of signals during thymocyte development. Nature, 2007 Volume 450(7170), 731-735.


Lessard J, Wu JI, Ranish JA, Wang M, Winslow MM, Staahl B, Wu H, Aebersold R, Graef IA, and Crabtree GR. (2007) An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron, 2007 Volume 55(2), 201-15.


Cante-Barrett K, Winslow MM, and Crabtree GR. (2007) Selective role of NFATc3 in positive selection of thymocytes. The Journal of Immunology, 2007 Volume 179(1), 103-110.


Pan M, Winslow MM, Chen L, Kuo A, Felsher D, Crabtree GR. Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulation. The Journal of Immunology 2007 Apr 1;178(7):4315-21.



Winslow MM, Pan M, Starbuck M, Gallo EM, Deng L, Karsenty G, and Crabtree GR. (2006) Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Developmental Cell, 2006 Volume 10(6), 771-782.


Heit JJ, Apelqvist AA, Gu X, Winslow MM, Neilson JR, Crabtree GR, and Kim SK. (2006) Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature, 2006 Volume 443(7109), 345-349.


Arron J*, Winslow MM*, Polleri A*, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim S, Yamasaki N, Miyakawa T, Franke U, Graef IA*, and Crabtree GR. (2006) NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on Chromosome 21. Nature (Article), 2006 Volume 441(7093), 595-600. *Contributed equally.


Staton TL, Habtezion A, Winslow MM, Sato T, Love PE, and Butcher EC. (2006) CD8 recent thymic emigrants efficiently home to and populate the small intestine epithelium. Nature Immunology, 2006 Volume 7(5), 482-488.


Winslow MM, Gallo EM, Neilson JR, and Crabtree GR. (2006) The Calcineurin Phosphatase Complex Modulates Immunogenic B cell Responses. Immunity, 2006 Volume 24(2), 141-52.



Neilson JR, Winslow MM, Hur EM, and Crabtree GR. (2004) Calcineurin B1 is essential for positive but not negative selection during thymocyte development. Immunity, 2004 Volume 20(3), 255-266.


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